The International Fertilizer Development Center (IFDC) aims to enhance food production with minimal land and water usage, improve climate resilience in farming, and reduce environmental impacts. The research focuses on nutrient use efficiency, soil health, and balanced fertilization for smallholder farmers globally. In 2021, the research emphasized improving soil health in sub-Saharan Africa, focusing on enhancing the efficiency of fertilizers. A collaborative study evaluated 16 nitrogenous and 12 phosphatic fertilizers under identical conditions using decision support tools and soil analyses. To benefit the economy and the environment, efforts were made to improve nutrient use efficiency, especially for nitrogen and phosphorus. Additionally, the project worked on nutrient omission trials in Ethiopia to evaluate crop response to different nutrient combinations and rates, including sulfur, zinc, and boron. The research also explored the activation of natural phosphate rock to improve its effectiveness in Niger and conducted trials with microbial biofertilizers.